The above registry files will modify the following Registry keys and values.
Use it to re-enable Defender later, and restart the OS after applying it. The ZIP archive contains the undo file, called Restore Windows Defender in Windows 10.reg. You can place the files directly to the Desktop.
Otherwise you won't be able to permanently disable the app. Disable the Tamper Protection feature.Temporarily Enable or Disable Microsoft Windows Defender To Disable Windows Defender in Windows 10